our_technology

Technology

State-of-the-art hyphenated Mass Spectrometry

ThetaBiomarkers' technologies are based on state-of-the-art hyphenated Mass Spectrometry. In 30 years of R&D we developed and validated dozens of HILIC-MS/(MS), RPLC-MS(/MS) and GC-MS(/MS) methods.

Liquid chromatography-tandem mass spectrometry (LC-MS) provides the preferred method for the efficient and sensitive quantitation of biomolecules and drugs and represents the workhorse in our lab.

Gas chromatography mass spectrometry (GC-MS) is the leading technology for (semi-)volatile analytes.

Our portfolio of analyses includes several TRL8 protocols and more than 50 methods validated at fit for purpose base.

Our technology and services employ
the following instrumentation

Time of flight mass spectrometry

TIMS-TOF-MS (Bruker), UPLC-Premier qTOF-MS (Waters)

Triple quadrupole MS/MS

Xevo TQD MS/MS (Waters), API 3200 with ESI and APCI probes (ABI Sciex)

Single quadrupole MS

ABI Sciex 150 LC-MS

UHPLC/HPLC systems

Acquity (Waters), Elute (Bruker) with a variety of detectors HPLC Alliance Waters with PDA and fluorescence detector

GC-MS/MS

EVOQ TQ (Bruker) including liquid injection, HS and SPME capabilities

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Further to these, special software is used, and validated in collaboration with software developers, and bespoke algorithms are developed for data mining. Through the analyses of thousands of real samples metabolite databases with concentration reference ranges have been established for aminoacids, organic acids, ceramides, fatty acid,s acyl carnitines and other biomarkers. Our findings have been presented in various conferences, meetings and have been published after peer reviewing.

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Our Technology